Respiratory Rhythm

Development of respiratory rhythm generation.

THERE HAVE BEEN very significant advances in our understanding of how respiratory rhythm is generated in mammals [see Feldman and Del Negro (2) for review]. This has provided the fundamental background on which to pursue investigations into how the system develops during the perinatal period. Respiratory rhythmogenesis is not only essential for postnatal survival but it is required in utero. Fa...

Respiratory rhythm generation in vivo.

The cellular and circuit mechanisms generating the rhythm of breathing in mammals have been under intense investigation for decades. Here, we try to integrate the key discoveries into an updated description of the basic neural processes generating respiratory rhythm under in vivo conditions.

Respiratory Rhythm An Emergent Network Property?

We tested the hypothesis that pacemaker neurons generate breathing rhythm in mammals. We monitored respiratory-related motor nerve rhythm in neonatal rodent slice preparations. Blockade of the persistent sodium current (I(NaP)), which was postulated to underlie voltage-dependent bursting in respiratory pacemaker neurons, with riluzole (< or =200 microM) did not alter the frequency of respirator...

The respiratory rhythm in nervous disorders.

Respiratory rhythm entrainment by somatic afferent stimulation.

Respiratory and locomotor patterns are coupled during locomotion. The objectives of this study were to (1) demonstrate that respiratory rhythms are entrained by sensory input from somatic afferents, (2) establish whether the parabrachial nucleus mediates entrainment, (3) examine responses of single respiratory neurons in the ventral respiratory group (VRG) to somatic afferent stimulation, and (...